News
- Dec 28
Suean Fontenard Named to Cell Mentor’s 1,000 Inspiring Black Scientists in America
Suean Fontenard, a postdoc in Speck Lab, has been named to Cell Mentor’s list of 1,000 Inspiring Black Scientists in America. The distinction aims to “dismantle the myth that outstanding
- May 01
Nancy A. Speck elected into the National Academy of Sciences
Dr. Nancy A. Speck has been inducted into the National Academy of Sciences in recognition of her distinguished and continuing achievements in original research. Congratulations, Nancy!
- Oct 17
Former Speck Lab Member Wins Nikon Competition
Dr. Amanda Phillips Yzaguirre, former Speck Lab member, recently made the top 20 list of winners in the 2018 Nikon Photomicrophy Competition. Dr. Yzaguirre, a postdoc at the Salk Institute
- Mar 03
Dr. Nancy Speck Recipient of 2018 ISEH Donald Metcalf Award
Congratulations to Dr. Nancy Speck, winner of the 2018 Donald Metcalf Award given by the International Society of Experimental Hematology (ISEH)! The award was established in 1999 in honor
Selected Publications
Zezulin AU, Yen D, Ye D, Howell ED, Bresciani E, Diemer J, Ren J, Ahmad MH, Castilla LH, Touw IP, Minn AJ, Tong W, Liu PP, Tan K, Yu W*, Speck NA* RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils. Genes Dev. 37, 605-620 (*corresponding authors) (2023).
Howell ED, Yzaguirre AD, Gao P, Lis R, He B, Lakadamyali M, Rafii S, Tan K*, Speck NA* Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes. Genes Dev. 35: 1475-1489 (*corresponding authors) (2021).
Bellissimo DC, Chen CH, Zhu Q, Bagga S, Lee CT, He B, Wertheim GB, Jordan M, Tan K, Worthen GS, Gilliland DG, Speck NA: Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling. Blood Adv. 4(6): 1145-1158 (2020).
Gao P, Chen C, Howell ED, Li Y, Tober J, Uzun Y, He B, Gao L, Zhu Q, Siekmann AF, Speck NA, Tan K: Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells. Genes Dev. 342(13-14): 950-964 (2020).
Zhu Q, Gao P, Tober J, Bennett L, Chen C, Uzun Y, Li Y, Howell ED, Mumau M, Yu W, He B, Speck NA, Tan K.: Developmental trajectory of prehematopoietic stem cell formation from endothelium. Blood. 136: 845-856 (2020).
Tober J, Maijenburg MMW, Li Y, Gao L, Hadland BK, Gao P, Minoura K, Bernstein ID, Tan K, Speck NA. Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1. J Exp Med. 2018 Feb 5;215(2):645-659.